Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders

Oxytocin is a hormone associated with reproduction, positive emotions and bonding in mammals. A diagnostic hallmark of autism spectrum disorders is a qualitative impairment in social communication and interaction. Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems.

Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders

Lambert, and Ian B. A diagnostic hallmark of autism spectrum disorders is a qualitative impairment in social communication and interaction. Deficits in the ability to recognize the emotions of others are believed to contribute to this.

There is currently no effective treatment for these problems. Participants then completed the Reading the Mind in the Eyes Task, a widely used and reliable test of emotion recognition.

In comparison with placebo, oxytocin administration improved performance on the Reading the Mind in the Eyes Task. This effect was also shown when analysis was restricted to the younger participants aged 12 to 15 who received the lower dose.

This study provides the first evidence that oxytocin nasal spray improves emotion recognition in young people diagnosed with autism spectrum disorders. Findings suggest the potential of earlier intervention and further evaluation of oxytocin nasal spray as a treatment to improve social communication and interaction in young people with autism spectrum disorders.

Autism, developmental disorders, emotion, emotion improves emotion recognition 7 and face processing 8. This recognition, face, oxytocin, social cognition has led some to speculate its use for the treatment of psychiatric disorders characterized by social deficit 6.

For this study, we investigated the effect of oxytocin admin- T he ability to understand emotion in others is essential for the healthy development of all mammals. It guides re- istration on emotion recognition for young people with autism sponse and decision making to social cues e.

We hypothesized that oxytocin nasal spray sion and enhances capacity to develop social bonds and to may lead to a brief, safe, and effective intervention to remedy nurture 1. In humans, abnormalities of emotion perception may emotion recognition deficits.

As far as we are aware, this is the contribute to psychiatric disorders associated with social prob- first report examining the effect of oxytocin nasal spray in a lems e. These emotion perception deficits have proven ex- ments in core symptoms, particularly if addressed early in life, ceedingly difficult to treat, with no robust empirical evidence for may result in better functional outcomes.

Methods and Materials Autism is the prototype disorder of social dysfunction. These are specific impairments related to social cognition, through local advertisement. In a double-blind, crossover, and which are likely to be heritable 4.

They are believed to play a randomized controlled trial, participants were assigned to re- key role in the failure to acquire social skills across developmen- ceive a single dose of oxytocin and a placebo nasal spray 1 week tal stages and are prognostic factors in early childhood for later apart.

Nasal sprays were developed by a compounding chemist diagnosis and for functioning in social settings 5. In typical healthy humans, oxytocin nasal administration 7,8.

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One year-old participant was stabilized on fluoxetine, Address correspondence to Adam J. When either or both of aguastella med. Participants re- quired an autism screening score of 17 or above 10 to progress Results further.

Participants then provided evidence of a documented Eight participants received oxytocin and eight received the mental age of 12 or greater as indicated by cognitive assessments placebo at the first test session.

One participant repeatedly fell conducted within the past 3 years. In the absence of previous asleep during testing, a noted symptom for the child, and was testing, participants were assessed by a neuropsychologist using excluded from analysis.

In comparison with performance under the age-appropriate Wechsler Intelligence Scale 11, We then split items into easy and hard assessment criteria and case review. These were additionally items 7.

The effect of oxytocin was highly significant for the reviewed by a multidisciplinary team. Analysis was also female gender and known allergy to preservatives contained in restricted to participants under the age of 16, given they received the nasal spray viz.

Participants were instructed to abstain from alcohol and oxytocin to this age group. Results again showed the beneficial caffeine on the day of drug administration and food and drink effect of oxytocin on emotion recognition performance for except water 2 hours before drug administration. Under oxytocin, participants reported they could withdraw at any time.

Under by the University of Sydney Ethics Committee Based on previous oxytocin and related peptide nasal spray Discussion research 7,8,15we presented the Reading the Mind in the Eyes Test-Revised RMET 16 45 minutes following drug administra- Our findings reveal that oxytocin nasal spray improves emo- tion.

Emotion recognition impairments are a core feature of used test of emotion recognition in patients with autism It has long been considered to have a heritable confirmed that the test had been previously used in high- base 4 that may be too difficult to effectively treat.

We are not functioning autism samples aged as young as 12 O.title = "Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders", author = "Adam Guastella and Stewart Einfeld and Kylie Gray and Rinehart, {Nicole Joan} and Bruce Tonge and Timothy Lambert and Ian Hickie".

Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders – Source: Biological Psychiatry, Apr 1, a widely used and reliable test of emotion recognition. Oxytocin Improves Emotion Recognition in Autism Oxytocin helped Autism Spectrum Disorders recognize some types of emotions.

Posted Oct 17, BRIEF REPORT Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders Adam J. Guastella, Stewart L. Einfeld, Kylie M. Gray, Nicole J. Rinehart, Bruce J. Tonge, Timothy J.

Lambert, and Ian B. Hickie Background: A diagnostic hallmark of autism spectrum disorders is a qualitative impairment in social communication and interaction. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.

Biological Psychiatry 67, – Guastella AJ, Howard AL, . The article is “Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders” by Adam J.

Guastella, Stewart L. Einfeld, Kylie M.

Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders

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